If I recall correctly, it’s not infamous for being super depressing but because it used to be a light hearted web comic (CTRL+ALT+DEL) about nerds doing nerd stuff and then the author decided to go into this weird dramatic arch of an ongoing love story that just didn’t really fit into the whole thing. The “Loss” strip was the overly dramatic peak of this arch and I think at this point people were already making fun of it. While the topic certainly is pretty depressing, it was more the fact that this whole thing was rather cringeworthy and over the top that started the whole meme.
If I recall correctly, it’s not infamous for being super depressing but because it used to be a light hearted web comic (CTRL+ALT+DEL) about nerds doing nerd stuff and then the author decided to go into this weird dramatic arch of an ongoing love story that just didn’t really fit into the whole thing. The “Loss” strip was the overly dramatic peak of this arch and I think at this point people were already making fun of it. While the topic certainly is pretty depressing, it was more the fact that this whole thing was rather cringeworthy and over the top that started the whole meme.