• 4 Posts
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Joined 1 year ago
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Cake day: May 23rd, 2024

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  • It’s possible they haven’t discovered why yet.
    So far, I’ve found two things.

    • The pyroptosis pathway triggered is the typical one (lots of Caspase-1 proteins get assembled into a giant inflammosome complex and attack Gasdermin D, which then starts poking holes in the cell membrane).
    • The EPS3.9 molecule has a high affinity for a five separate membrane lipids.

    But without any formal biochemistry training, I am missing a lot of prerequisite knowledge.

    Is that high affinity above normal? Does it need to bind all five to enter the cell, or just any of them? Are those lipids, or that combination of lipids, exclusive to tumor cells? I have no info on any of these questions.

    It’s also entirely possible that it’s attacking healthy liver cells too, just at a reduced rate due to cancer cells being resource hogs.










  • Peaceful. Heh. It definitely used to be peaceful, kiddo…
    But those days are so long gone, and the moon so scarred, that those days might as well be out of a fantasy novel.

    What happened, you ask? Heh… That’s a silly question. Human nature happened.

    You see, transit to Europa was never commercialized. Not back then, and now likely never will be. And yet, humans still charged forward, to that pristine icy moon. Charging so far off the beaten paths. Away from comforts, away from contact, away from society itself… Ask yourself now, what sort of man would willingly throw themselves such absolute solitude?

    Prideful, arrogant, and sometimes even criminal, for a moment, Europa was a haven to it all. An age of constant advancement, stoked by the fires of so many supreme wills.

    It was never destined to last.

    Amidst that multitude, a hunger as old civilization grew. The hunger of dominion, festering in a place packed to the brim with wolves, but not a single sheep. Is it any wonder, then, that all it took was a single spark of prideful dissent? Just one, and it all gave way.

    To want.
    To discord.
    To violence.
    To insanity.
    To ruin.

    No one can stop you if you really want to go, kiddo. Actually no, that’s not entirely true. You’ll probably get interdicted and arrested on the way back. So I’ll just tell you right now, there is nothing left.
    Only ash, ice, and the remains of the fools of that age. Magnificent fools, but fools nonetheless.








  • Do keep the glass transition temperatures for your filaments in mind. 150°, or even 165°F may be fine for PETG, but PLA will soften at those temps. Also, check your local liquor stores for anything in the 95% range. Makes a great cleaner in general, and should take care of any unforeseen offgassed chemical deposit issues.

    Even though I expect any such volatiles to remain a gas and get shot out the exhaust, it’s better to be safe.


  • Probably not, but the goal is the convenience of multi-purpose. I can dry a filament for an hour, then wipe down the inside, load the dried filament, and cook dinner while I print.

    Also banking on the air fryers capacity to blow larger volumes of hot air at the target temp, given that… Well, it’s designed to mainly cook food. Some of the cheaper filament dryers just do not have enough airflow. Or any airflow.